Our lab investigates the molecular mechanisms of signal
propagation and signal termination in the phospholipase C (PLC) and PI3
kinase (PI3-K) signaling pathways.
We focus on how protein kinase C and Akt (protein kinase B) are 1] activated by phosphorylation and second messengers, and 2] inactivated by dephosphorylation catalyzed by the new phosphatase PH domain Leucine rich repeat Protein Phosphatase, PHLPP (pronounced 'flip'). Understanding the molecular mechanisms of these processes is of particular relevance to disease where many of these proteins become deregulated.