Alexandra Newton Lab

In the News

Press releases for Alfonso et al. 2016
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease.
Sci. Signal. 10 May 2016: Vol. 9, Issue 427, pp. ra47
- Therapy that failed with cancer could fight Alzheimer's
- Genetic Variations that Boost PKC Enzyme Contribute to Alzheimer’s Disease

PKCα in Alzheimer’s disease
Podcast for Alfonso et al. 2016
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease.
Sci. Signal. 10 May 2016: Vol. 9, Issue 427, pp. ra47

Corrected Protein Structure Reveals Drug Targets for Cancer, Neurodegenerative Diseases
Press release for Antal et al. 2015
Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.
Cell Rep. 2015 Aug 25;12(8):1252-60.

Cure Alzheimer's Fund
Featured Researcher: Alexandra Newton, Ph.D.
‘Cancer Protein’ Linked to Alzheimer’s.

Press releases for Antal et al. 2015
Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor.
Cell. 2015 Jan 29;160(3):489-502.

- Enzymes believed to promote cancer actually suppress tumors.
- Suspected cancer promoter actually suppresses tumors.

The Goldilocks effect in cancer.
Press release for Wang et al. 2014
Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt.
Mol Cell. 2014 May 8;54(3):378–91.

Prostate cancer advance promises better diagnosis, treatment.
Press release for Chen et al. 2011
Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression.
Cancer Cell. 2011 Aug 16;20(2):173-86.

ASBMB Today from July 2007 highlights PKC on its cover and Newton lab research - see article on p. 27 - 29. PDF

UCSD Researchers Discover Variants of Natural Tumor Suppressor
Press release for Brognard J, Sierecki E, Gao T, Newton AC. 
PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms. 
Mol Cell. 2007 Mar 23;25(6):917-31.

Natural Tumor Suppressor in Body Discovered by UCSD Medical Researchers
Press release for Gao T, Furnari F, Newton AC.
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Mol Cell. 2005 Apr 1;18(1):13-24.